Yes, you can! Printful has fulfillment centers in the US, Europe, and Mexico. We recommend using all of our locations for your orders so we can route them to where we can fulfill and ship them most efficiently. If you disable our Europe fulfillment center, for example, your European customers might not be happy about extra shipping time and customs fees.
If you want your orders to only get routed to specific regions, go to Settings → Orders → Order routing.
Keep in mind that if a product in an order is unavailable at one of your preferred locations, we'll put the order on “needs approval” and get in touch with you about how you'd like to move forward.